#SPINDLE CELL SARCOMA SERIES#

According to the survival analyses depending on demographic factors such as age, gender and race, it demonstrates that only age is an independent prognostic indicator for SCS in DSS and OS. Besides, the overall race distribution includes 80.9% white, 11.4% black, 7.8% American Indian/Asian/Pacific Islander (Table 1). However, there is predominance in male with a sex predilection of 1.11:1 male: female ratio in a previous report 22. In addition, there is no statistically significant difference on incidence rate in gender. In this series, SCS most frequently occurs during the seventh decades of life with the mean age at diagnosis of SCS is 61 years. SCS occur more commonly in middle and old age adult groups. To address these, a retrospective investigation was carried out with study population from Surveillance, Epidemiology, and End Results (SEER) database.Īccording to current investigation, SCS affects people of almost all ages which was as same as soft tissue sarcomas 21.

However, owing to the rarity of SCS, there are lack of basic information regarding the tumor incidence, distinctive clinical characteristics, treatment outcome and disease specific prognostic factors. Nowadays, the sophisticated molecular pathologic diagnostic techniques has made the diagnosis of SCS accurate and reliable 2.

Like other sarcoma, SCS were treated aggressively with surgical therapy as a mainstay in the management and adjuvant (chemo) radiotherapy was implemented for patients with high risk behavior 2, 5, 7, 9, 10, 13, 15, 16, 17, 18. According to these case reports, the clinical presentations of SCS were similar to the benign lesion at early stage 11, 12, 13, 14, 15, 16, 17, 18.

#SPINDLE CELL SARCOMA SERIES#

As such, SCS constitutes a diagnostic and therapeutic challenge 10, 11.Īs morbidity, majority of the previous reports were single case reports and retrospective case series with more than five patients were even few. Only a handful of cases have been reported around the world from variety of body parts 3, 4, 5, 6, 7, 8, 9. It is a type of connective tissue tumor and generally begins in layers of connective tissue such as that under the skin, between muscles, and surrounding organs. Primary spindle cell sarcoma (SCS) is an extremely rare entity and one of the least reported tumor 2. Spindle cell neoplasm are diverse in nature by means of clinicopathologic and tumor biological heterogeneity 1. The patient’s age, AJCC stage, tumor location and surgery were independent prognostic indicators for both DSS and OS of SCS. In brief, our study demonstrated that SCS mostly found in white people at fifth to seventh decades of life without gender predilection. In the multivariate Cox analysis, the age >64 years (for DSS, P < 0.001 and for OS, P < 0.001 Reference age ≤64 years), AJCC stage III (for DSS, P = 0.006 and for OS, P = 0.04 Reference: AJCC stage I), and non-surgical treatment (for DSS, P < 0.001 and for OS, P < 0.001 Reference: surgery) were independently associated with worse DSS and OS. Significant disease specific survival (DSS) and overall survival (OS) were found differentiated in age, T stage, N stage, M stage, AJCC stage, SEER historic stage, tumor locations, surgery, and pathologic grade. White people account for 79.1% with median age of 57 years without predominance in any gender.

3299 SCS cases were identified and extracted from Surveillance, Epidemiology, and End Results (SEER) database (1973–2017). In this study, we investigated the clinical characteristics and disease specific prognostic factors of SCS. Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively.